Vancouver Back Pain Related to Inflammation Reduced with Melatonin

Inflammation. Disc Degeneration. There is a relationship. Inflammation is the body’s response to harmful stimuli (injury, pathogens, metabolic stress – a disc herniation pushing on a nerve!) as it tries to restore itself to normal before the harm was achieved. Vancouver Spine Care Centre is never shocked at what the body can do! Vancouver Spine Care Centre sees its Vancouver chiropractic care as a partner of the body’s system in healing particularly when spine pain is an issue. Chiropractic care utilizes many tools like spinal manipulation, exercise, and nutrition to take care of the body. Melatonin is one nutritional tool that is showing value by interrupting the inflammatory process related disc herniation that results in back pain, neck pain and other spine related pain.

DISC DEGENERATION AND INFLAMMATION AND 'AUTOPHAGY'

Inflammatory markers interleukin-1β (IL-1β), interleukin-6 (IL-6) and tumor necrosis factor-α (TNF-α) are associated with intervertebral disc degeneration. (1) IL-1 β actually promotes itself, its own expression, by upregulating NLRP3 inflammasome activation. (2) The body regulates itself down to the cellular level via autophagy, the natural process during which the body’s cells clean out damaged (ie, by inflammation) or unneeded parts. In a new study, melatonin increased autophagy and decreased the degradation of the disc’s extracellular matrix (technically indicated by a decrease in marker LC3B, autophagasomes and autolysosomes and inhibition of the NF-kB signaling pathway). The final conclusion was that melatonin prevents intervertebral disc degeneration by promoting autophagy. (3) Wow. Vancouver Spine Care Centre is encouraged by this research to see just how well melatonin can work for Vancouver back pain related to disc degeneration.

MELATONIN AND ITS HEALING WAYS FOR THE DISC

Disc degeneration is quite a common malady seen at Vancouver Spine Care Centre that positive news of melatonin’s benefits are quite exciting. A new study explained how melatonin could modify the extracellular matrix of the disc remodeling process initiated by IL-1 β. Additionally, melatonin decreased the inflammatory cell collection and reduced the release of associated inflammatory markers IL-1β, IL-6, and TNF-α. With this new discovery that melatonin interrupted the IL-1B feedback loop, researchers postulated that melatonin may support the restoration process of intervertebral discs after damage was already present. (1) Vancouver Spine Care Centre continues following the new research regarding the role inflammation plays in Vancouver disc degeneration and melatonin’s role in tackling it.

INFLAMMATION AND MELATONIN

The significance of melatonin in assisting to slow or stop painful conditions due to inflammation is rising. The description of melatonin as a multitasking molecule influencing mood, immunity, and energy among other things is quite appropriate. It is also anti-oxidant, anti-aging, and anti-inflammatory, specifically by hindering the activation of inflammasomes (4) Melatonin’s formal chemical name is as about as long as its list of tasks: N-acetyl-5-methoxytryptamine. The pineal gland secretes melatonin naturally. Melatonin influences the body’s aging, anti-inflammatory, anti-apoptosis (cell death), and autophagy (cell-cleanout) activities. (1) Melatonin’s specific influence on inflammation and disc degeneration is most interesting to Vancouver Spine Care Centre and our Vancouver back pain patients.

CONTACT Vancouver Spine Care Centre

Listen to this PODCAST with Dr. Hrefna Sylvia based in Iceland where back pain isn’t much different from any other country on The Back Doctors Podcast with Dr. Michael Johnson as she illustrates how The Cox® Technic System of Spinal Pain Management manages disc degeneration for relief of chronic low back pain in her patient.

Schedule your Vancouver chiropractic appointment with Vancouver Spine Care Centre soon. We can talk about how inflammation affects your back pain and how melatonin may address the related disc degeneration.

 
Vancouver Spine Care Centre presents new findings that melatonin interrupts the inflammatory process in disc degeneration that causes back pain. 
 
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"This information and website content is not intended to diagnose, guarantee results, or recommend specific treatment or activity. It is designed to educate and inform only. Please consult your physician for a thorough examination leading to a diagnosis and well-planned treatment strategy. See more details on the DISCLAIMER page. Content is reviewed by Dr. James M. Cox I."