Inflammation. Disc Degeneration. There is a relationship.
Inflammation is the body’s response to harmful
stimuli (injury, pathogens, metabolic stress – a disc herniation pushing
on a nerve!) as it tries to restore itself to normal
before the harm was achieved. Vancouver Spine Care Centre is never
shocked at what the body can do!
Vancouver Spine Care Centre sees its Vancouver chiropractic care as a partner of
the body’s system in healing particularly
when spine pain is an issue. Chiropractic care utilizes
many tools like spinal manipulation, exercise, and nutrition to take care of
the body. Melatonin is one nutritional tool that is showing value
by interrupting the inflammatory process
related disc herniation that results
in back pain, neck pain and other spine related pain.
DISC DEGENERATION AND INFLAMMATION AND 'AUTOPHAGY'
Inflammatory markers interleukin-1β (IL-1β), interleukin-6
(IL-6) and tumor necrosis factor-α (TNF-α) are associated with intervertebral disc degeneration. (1) IL-1 β actually promotes
itself, its own expression, by upregulating NLRP3 inflammasome activation. (2)
The body regulates itself down to the cellular level
via autophagy, the natural process during which the body’s
cells clean out damaged (ie, by inflammation) or unneeded parts. In
a new study, melatonin increased autophagy
and decreased the degradation of the disc’s
extracellular matrix (technically indicated by a decrease
in marker LC3B, autophagasomes and autolysosomes and inhibition of the NF-kB
signaling pathway). The final conclusion was that melatonin prevents
intervertebral disc degeneration by promoting autophagy. (3)
Wow. Vancouver Spine Care Centre is encouraged by this research to see just
how well melatonin can work for Vancouver back pain related
to disc degeneration.
MELATONIN AND ITS HEALING WAYS FOR THE DISC
Disc degeneration is quite a common malady
seen at Vancouver Spine Care Centre that positive news of
melatonin’s benefits are quite exciting. A new
study explained how melatonin could modify
the extracellular matrix of the disc remodeling process initiated
by IL-1 β. Additionally, melatonin decreased the
inflammatory cell collection and reduced the release of associated
inflammatory markers IL-1β, IL-6, and TNF-α. With this new discovery
that melatonin interrupted the IL-1B feedback loop, researchers
postulated that melatonin may support
the restoration process of intervertebral discs after damage was
already present. (1) Vancouver Spine Care Centre continues
following the new research regarding the role inflammation plays
in Vancouver disc degeneration and melatonin’s role in tackling
INFLAMMATION AND MELATONIN
The significance of melatonin in assisting
to slow or stop painful conditions due to inflammation is rising.
The description of melatonin as a multitasking molecule influencing
mood, immunity, and energy among other things is quite appropriate.
It is also anti-oxidant, anti-aging, and anti-inflammatory, specifically
by hindering the activation of inflammasomes (4) Melatonin’s
formal chemical name is as about as long as its list of tasks: N-acetyl-5-methoxytryptamine.
The pineal gland secretes melatonin naturally. Melatonin influences
the body’s aging, anti-inflammatory, anti-apoptosis (cell death), and autophagy
(cell-cleanout) activities. (1) Melatonin’s specific influence on
inflammation and disc degeneration is most interesting
to Vancouver Spine Care Centre and our Vancouver back pain patients.
CONTACT Vancouver Spine Care Centre
Listen to this PODCAST
with Dr. Hrefna Sylvia based in Iceland where back pain isn’t much different
from any other country on The Back Doctors Podcast with Dr.
Michael Johnson as she illustrates how The Cox® Technic
System of Spinal Pain Management manages disc
degeneration for relief of chronic low back pain in her patient.
Schedule your Vancouver chiropractic appointment with
Vancouver Spine Care Centre soon. We can talk about how inflammation affects your
back pain and how melatonin may address the related disc